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Related Experiment Video

Updated: Jun 30, 2025

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

Wound microenvironment-responsive peptide hydrogel with multifunctionalities for accelerating wound healing.

Weimiao Dong¹, Haihong Yang¹, Min Liu^1,2

¹Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, China.

Journal of Peptide Science : an Official Publication of the European Peptide Society

|March 17, 2024

Summary

This study presents a novel peptide hydrogel (Pep-1/NMB) that responds to wound conditions. This advanced wound dressing offers rapid hemostasis, potent antibacterial action, and promotes faster healing.

Keywords:

antibacterial activity hemostatic ability peptide hydrogel wound healing wound microenvironment‐responsive

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Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Developing effective wound dressings with multiple functionalities like hemostasis, antibacterial properties, and wound healing acceleration is crucial.
Existing treatments often lack the ability to respond to the dynamic wound microenvironment, limiting their efficacy.

Purpose of the Study:

To construct a multifunctional, wound microenvironment-responsive peptide hydrogel dressing.
To evaluate the hemostatic, antibacterial, and wound healing capabilities of the developed hydrogel.

Main Methods:

Fabrication of a peptide hydrogel (Pep-1/NMB) via electrostatic interaction and self-assembly.
Characterization using electron microscopy, spectroscopy, Zeta potential, and rheological analysis.
In vitro and in vivo assays for drug release, antibacterial activity, hemostasis, biocompatibility, and wound healing.

Main Results:

The Pep-1/NMB hydrogel demonstrated controlled self-assembly and faster drug release in acidic conditions.
Photothermally enhanced antibacterial activity reached 95.3% upon 635 nm laser irradiation.
Effective hemostasis in vitro and in a mouse liver hemorrhage model, with excellent hemocompatibility and cytocompatibility.
Significant promotion of cell migration and wound repair observed in healing studies.

Conclusions:

The wound microenvironment-responsive Pep-1/NMB hydrogel serves as a promising platform for advanced wound dressings.
The hydrogel offers rapid hemostasis, potent antibacterial effects, and accelerates wound healing.