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Updated: Jun 30, 2025

RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes
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RNA Catalyst as a Reporter for Screening Drugs against RNA Editing in Trypanosomes

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From a bimodal to a multi-stage view on trypanosomes' differential RNA editing

Homa Zamani1, Naghmeh Poorinmohammad1, Amin Azimi1

  • 1Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3V9, Canada.

Trends in Parasitology
|March 17, 2024
PubMed
Abstract

Keywords:
RNA editingRNA editing machinery dynamicsomics approaches in parasite adaptation

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RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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