H pylori-Negative MALT-Associated Extranodal Marginal Zone Lymphoma: A Comprehensive Case Report and Literature
Ammar Qureshi1, Akash Patel2, Adewale B Ajumobi1,2
1University of California, Riverside, USA.
Journal of Investigative Medicine High Impact Case Reports
|March 18, 2024
Summary
This study details two rare cases of Helicobacter pylori-negative colonic extranodal marginal zone B-cell lymphoma (ENMZL). Findings emphasize the need for considering H pylori-negative ENMZL in diagnosis and management.
Area of Science:
- Oncology
- Hematology
- Gastroenterology
Background:
- Extranodal marginal zone B-cell lymphoma (ENMZL) of mucosa-associated lymphoid tissue (MALT) is a rare B-cell lymphoma.
- Gastric ENMZL is commonly associated with Helicobacter pylori (H pylori) infection.
- This study explores H pylori-negative colonic ENMZL, challenging typical associations.
Approach:
- Presents two unique case studies of H pylori-negative colonic ENMZL in elderly males.
- Includes a comprehensive literature review on H pylori-negative ENMZL, focusing on gastrointestinal involvement.
- Examines epidemiology, pathology, clinical features, diagnosis, and treatment strategies.
Key Points:
- Reports two distinct cases of extranodal marginal zone B-cell lymphoma in the descending and sigmoid colon.
- Neither patient had a detectable H pylori infection, complicating conventional diagnostic and treatment pathways.
- Literature review underscores the significance of H pylori-negative ENMZL in clinical practice.
Conclusions:
- H pylori-negative ENMZL, particularly in the colon, represents an uncommon but important subtype.
- Highlights the necessity of considering non-H pylori-associated cases in ENMZL diagnosis.
- Advocates for further research and tailored treatment approaches for this rare lymphoma subtype.
Keywords:
H pylori-negative extranodal marginal zone lymphomaMALT lymphomaextranodal marginal zone B-cell lymphomaextranodal marginal zone lymphomagastroenterologyhematology oncologymucosa-associated lymphoid tissue lymphomaMore Related Videos
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