Skin rejuvenation through topical application of indocyanine green with diffractive optical element mode of 785 nm picosecond laser in Asian females
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View abstract on PubMed
Summary
This summary is machine-generated.This study shows that combining indocyanine green (ICG) with a 785 nm picosecond laser effectively treats photo-aged skin, improving wrinkles, pores, and hyperpigmentation with minimal side effects.
Area Of Science
- Dermatology
- Aesthetic Medicine
- Laser Technology
Background
- Indocyanine green (ICG) has strong absorption properties near 800 nm.
- Photo-aged skin presents challenges in treatment due to wrinkles, pores, and hyperpigmentation.
Purpose Of The Study
- To evaluate the clinical efficacy of combining indocyanine green (ICG) with a 785 nm picosecond laser for treating photo-aged skin.
- To assess the impact on wrinkles, pores, and hyperpigmented lesions.
Main Methods
- 16 female patients (Fitzpatrick skin types III-IV) received five treatment sessions using a 785 nm picosecond laser with ICG cream.
- Treatments involved 3000 shots in diffractive mode and targeted application for hyperpigmented lesions.
- Skin assessments included the Modified Fitzpatrick Wrinkle Scale and visual analog scales; skin biopsies were analyzed.
Main Results
- Significant improvements were observed in wrinkles (p=0.02), pores (p=0.034), and hyperpigmentation (p=0.036).
- Histological analysis revealed increased and thickened dermal collagen, with elevated expression of collagen I, III, and STRO-1.
- Adverse effects were transient and well-tolerated by patients.
Conclusions
- The combination of a 785 nm picosecond laser and ICG demonstrates promising clinical results for photo-aged skin.
- This treatment approach is effective for Asian patients with Fitzpatrick skin types III and IV.
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