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PIEZO1 acts as a cancer suppressor by regulating the ROS/Wnt/β-catenin axis

Haimei Bo1,2, Qi Wu1, Chaonan Zhu2,3

  • 1Tianjin Medical University General Hospital, Tianjin, China.

Thoracic Cancer
|March 18, 2024
PubMed
Abstract

Insights

PIEZO1 acts as a cancer suppressor in lung adenocarcinoma by regulating the ROS/Wnt/β-catenin pathway. This discovery offers new insights into mechanosensitive channels in cancer progression.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • PIEZO1 exhibits varied roles in different cancers and developmental stages.
  • Understanding PIEZO1's specific function in lung adenocarcinoma (LUAD) is crucial.

Purpose of the Study:

  • To investigate the function of PIEZO1 in LUAD cells.
  • To elucidate the underlying molecular mechanisms of PIEZO1 in LUAD.

Main Methods:

  • LUAD cell lines were treated with PIEZO1 inhibitors (GsMTx4) and agonists (Yoda1).
  • PIEZO1 expression, cell proliferation, invasion, migration, apoptosis, and EMT markers were assessed.
  • The role of PIEZO1 in ROS production and Wnt/β-catenin signaling was investigated using specific agonists and inhibitors.

Main Results:

  • PIEZO1 inhibition (GsMTx4) promoted LUAD cell proliferation, invasion, migration, and EMT markers while inhibiting apoptosis.
  • PIEZO1 activation (Yoda1) showed opposite effects.
  • PIEZO1 modulated ROS production and apoptosis, and its effects were linked to the Wnt/β-catenin pathway.

Conclusions:

  • PIEZO1 functions as a tumor suppressor in LUAD.
  • PIEZO1 regulates cancer progression via the ROS/Wnt/β-catenin signaling axis.
  • This study provides a novel perspective on mechanosensitive channels in cancer.
Keywords:
EMTPIEZO1ROSWnt/β‐cateninlung adenocarcinoma

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