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Dynamic changes and clinical value of lipocalin 2 in liver diseases caused by microbial infections
Feng Chen1, Shan-Shan Wu1, Chao Chen1
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Abstract:
Lipocalin 2 (LCN2) plays a pivotal role in iron metabolism, particularly in the context of microbial infection resistance (e.g., viruses, bacteria, parasites, etc.). LCN2 combats microbial infection by directly assisting the body in competing with microorganisms for iron, inducing immune cells to secrete various cytokines to enhance systemic immune responses, or recruiting neutrophils to infectious sites. The liver serves as the primary organ for LCN2 secretion during microbial infections. This review encapsulates recent advances in dynamic changes, clinical values, and the effects of LCN2 in infectious liver diseases caused by various microbial microorganisms.
Insights
Lipocalin 2 (LCN2) is crucial for fighting microbial infections by managing iron and boosting immune responses. This review details LCN2
Area of Science:
- Biochemistry and Immunology
- Microbial Pathogenesis and Host Defense
- Hepatology and Infectious Diseases
Background:
- Lipocalin 2 (LCN2) is a key protein involved in iron metabolism and host defense against microbial infections.
- LCN2 functions by sequestering iron, modulating immune cell responses, and recruiting immune cells to infection sites.
- The liver is the primary site of LCN2 production during infection.
Purpose of the Study:
- To review recent advancements in understanding Lipocalin 2 (LCN2) in the context of infectious liver diseases.
- To summarize the dynamic changes, clinical significance, and functional roles of LCN2 during various microbial infections affecting the liver.
Main Methods:
- Literature review of recent studies on Lipocalin 2 (LCN2) and infectious liver diseases.
- Analysis of LCN2's role in iron metabolism and immune response modulation.
- Synthesis of data on LCN2's clinical relevance and dynamic expression patterns in liver infections.
Main Results:
- Lipocalin 2 (LCN2) demonstrates significant dynamic changes in infectious liver diseases.
- LCN2 exhibits considerable clinical value in diagnosing and managing various microbial liver infections.
- LCN2 plays multifaceted roles in combating microbial pathogens within the liver environment.
Conclusions:
- Lipocalin 2 (LCN2) is a critical mediator in the host's defense against microbial infections, particularly in the liver.
- Understanding LCN2 dynamics and functions offers potential therapeutic strategies for infectious liver diseases.
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