Related Experiment Video
Updated: Jun 30, 2025
Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
Published on: March 21, 2015
Anti-oxidative stress treatment and current clinical trials
1Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States.
Abstract:
Oxidative stress disturbs the balance between the production of reactive oxygen species (ROS) and the detoxification biological process. It plays an important role in the development and progression of many chronic diseases. Upon exposure to oxidative stress or the inducers of ROS, the cellular nucleus undergoes some biological processes via different signaling pathways, such as stress adaption through the forkhead box O signaling pathway, inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway, hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway, DNA repair or apoptosis through the p53 signaling pathway, and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling pathway. These processes are involved in many diseases. Therefore, oxidative stress has gained more attraction as a targeting process for disease treatment. Meanwhile, anti-oxidative stress agents have been widely explored in pre-clinical trials. However, only limited clinical trials are performed to evaluate the efficacy of anti-oxidative stress agents or antioxidants in diseases. In this letter, we further discuss the current clinical trials related to anti-oxidative stress treatment in different diseases. More pre-clinical studies and clinical trials are expected to use anti-oxidative stress strategies as disease treatment or dietary supplementation to improve disease treatment outcomes.
Insights
Oxidative stress, an imbalance in reactive oxygen species (ROS), is key in chronic diseases. While anti-oxidative stress agents show promise pre-clinically, more clinical trials are needed to confirm their efficacy in treating diseases.
Area of Science:
- Cellular Biology
- Biochemistry
- Pathophysiology
Background:
- Oxidative stress disrupts the balance between reactive oxygen species (ROS) production and detoxification.
- This imbalance is implicated in the development and progression of numerous chronic diseases.
- Cellular responses to oxidative stress involve various signaling pathways, including stress adaptation, inflammation, hypoxic response, DNA repair, and antioxidant response.
Purpose of the Study:
- To review current clinical trials investigating anti-oxidative stress treatments for various diseases.
- To highlight the gap between pre-clinical promise and clinical validation of anti-oxidative stress agents.
- To emphasize the need for further research in this therapeutic area.
Main Methods:
- Literature review of current clinical trials on anti-oxidative stress treatments.
- Discussion of the role of oxidative stress and related signaling pathways in disease.
- Analysis of the translational progress of anti-oxidative stress agents from pre-clinical to clinical settings.
Main Results:
- Oxidative stress is a significant factor in multiple disease pathologies.
- Various signaling pathways are activated by oxidative stress, offering therapeutic targets.
- Limited clinical trials have evaluated the efficacy of anti-oxidative stress agents, despite extensive pre-clinical research.
Conclusions:
- Oxidative stress represents a promising therapeutic target for a range of diseases.
- Further pre-clinical and clinical studies are essential to validate anti-oxidative stress strategies.
- Anti-oxidative stress agents may serve as disease treatments or dietary supplements to enhance treatment outcomes.
More Related Videos
Related Concept Videos
01:46Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
01:22Alzheimer's Disease: Treatment