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Metabolic-associated fatty liver disease and sarcopenia: A double whammy

Aditya Viswanath1, Sherouk Fouda2, Cornelius James Fernandez3

  • 1School of Medicine, Leicester University, Leicester LE1 7RH, United Kingdom.

World Journal of Hepatology
|March 18, 2024
PubMed

Insights

Metabolic-associated fatty liver disease (MAFLD) and sarcopenia often coexist, impacting patient health. Understanding their complex relationship is key to developing effective treatments for these interconnected conditions.

Area of Science:

  • Hepatology and Metabolic Disorders
  • Geriatric Medicine
  • Clinical Nutrition

Background:

  • Metabolic-associated fatty liver disease (MAFLD) prevalence is rising globally due to obesity.
  • MAFLD is the leading cause of chronic liver disease, exacerbating comorbidities like cardiovascular disease and type 2 diabetes.
  • Sarcopenia, or muscle loss, is increasingly recognized as a significant factor in MAFLD progression.

Purpose of the Study:

  • To elucidate the intricate pathobiological links between MAFLD and sarcopenia.
  • To provide a comprehensive clinical update on managing coexisting MAFLD and sarcopenia.
  • To propose evidence-based therapeutic strategies for patients with both conditions.

Main Methods:

  • Comprehensive review of current clinical literature on MAFLD and sarcopenia.
  • Analysis of pathobiological mechanisms connecting liver fat accumulation and muscle wasting.
  • Synthesis of evidence for therapeutic interventions.

Main Results:

  • Sarcopenia can be both a cause and consequence of MAFLD, particularly in advanced stages.
  • The interplay between MAFLD and sarcopenia negatively impacts exercise capacity and disease outcomes.
  • Muscle-related factors contribute to the worsening of MAFLD.

Conclusions:

  • A thorough understanding of the MAFLD-sarcopenia axis is critical for effective patient management.
  • Integrated therapeutic strategies addressing both conditions are necessary.
  • Further research into optimizing treatment for coexisting MAFLD and sarcopenia is warranted.
Keywords:
Cardiovascular diseaseLean metabolic-associated fatty liver diseaseLiver-muscle axisMetabolic-associated fatty liver diseaseSarcopeniaSarcopenic obesity

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