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Related Experiment Video

Updated: Jun 30, 2025

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
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Single-cell lineage tracing with endogenous markers.

Yan Xue1,2, Zezhuo Su1,2,3, Xinyi Lin1

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Biophysical Reviews
|March 18, 2024
PubMed
Summary
This summary is machine-generated.

Cell lineage tracing uses somatic mutations as DNA barcodes to understand development and disease. Advances enable single-cell resolution in humans, revealing cellular relationships during development and tumor evolution.

Keywords:
Mitochondrial mutationsSingle-cell lineage tracingSomatic nuclear mutationsSpatial clonal evolution

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Area of Science:

  • Genetics
  • Developmental Biology
  • Genomics

Background:

  • Understanding cell fate and relationships is crucial for development and disease research.
  • Somatic mutations serve as endogenous DNA barcodes for lineage tracing.
  • Recent advances allow single-cell resolution for lineage tracing in model organisms and humans.

Purpose of the Study:

  • To review experimental and computational techniques for cell lineage tracing using somatic mutations.
  • To discuss the advantages and challenges of these methods.
  • To explore the application of lineage tracing in development and tumor evolution.

Main Methods:

  • Utilizing naturally occurring somatic nuclear and mitochondrial mutations.
  • Applying single-cell resolution techniques.
  • Employing computational approaches for data analysis.

Main Results:

  • Somatic mutations provide endogenous genetic markers for deciphering cell relationships.
  • Single-cell lineage tracing offers insights into developmental processes.
  • Analysis of spatial clonal evolution aids in understanding tumor progression.

Conclusions:

  • Cell lineage tracing with somatic mutations is a powerful tool for studying development and disease.
  • Integrating experimental and computational methods enhances lineage tracing capabilities.
  • Future research can leverage these techniques for deeper biological insights.