Osteoporosis management-current and future perspectives - A systemic review.
Rajamohanan Jalaja Anish1, Aswathy Nair1
1Department of Biochemistry, University of Kerala, Kariyavattom Campus, Trivandrum, 695581, India.
Journal of Orthopaedics
|March 18, 2024
Summary
This review covers osteoporosis management, including lifestyle changes, medications, and advanced AI techniques to reduce fracture risk and improve quality of life in older adults.
Area of Science:
- Geriatric Medicine
- Metabolic Bone Disease
Background:
- Osteoporosis is a geriatric metabolic condition characterized by low bone mineral density (BMD) and compromised bone strength.
- It significantly increases fracture risk and negatively impacts quality of life, particularly in individuals over 55 (women) and 65 (men).
Purpose of the Study:
- To review current and advanced management strategies for osteoporosis.
- To explore methods for reducing osteoporosis complications and fracture risk.
Main Methods:
- Systematic review of scientific literature from 2008-2023.
- Inclusion and exclusion criteria applied to online scientific search engine data.
Main Results:
- Biochemical markers (BALP, collagen, osteocalcin, cathepsin-K) and DEXA scans aid in assessing osteoporotic status and BMD.
- Pharmacological approaches involve anabolic and anti-osteoporotic agents to modulate bone formation, resorption, and remodeling, with combination therapy potentially mitigating side effects.
Conclusions:
- Effective osteoporosis management encompasses lifestyle modifications (e.g., exercise), pharmaceutical interventions, and novel therapeutic avenues.
- Emerging technologies like Artificial Intelligence (AI) and machine learning show promise in further reducing osteoporosis complications and fracture risk.
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