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Updated: Jun 30, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins
Published on: March 7, 2018
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of
Sarah J Harmych1,2, Claiborne W Tydings3, Jens Meiler3,4
1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Abstract:
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolaterally-localized proteins lacking the canonical tyrosine- and dileucine-based basolateral sorting motifs, a monoleucine-based sorting motif has been identified. This review will discuss these proteins with an identified monoleucine-based sorting motif, their conserved structural features, as well as the future directions of study for this non-canonical basolateral sorting motif.
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