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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Post-Transplant Glomerulonephritis: Challenges and Solutions.

Marcos Vinicius de Sousa¹

¹University of Campinas, School of Medical Sciences, Department of Internal Medicine, Division of Nephrology, Renal Transplant Unit, Transplant Research Laboratory, Campinas, SP, Brazil.

International Journal of Nephrology and Renovascular Disease

|March 18, 2024

Summary

This summary is machine-generated.

Kidney transplant recipients face glomerular damage from recurrent or new glomerulonephritis (GN) and viral infections. Early diagnosis and monitoring are crucial for graft survival.

Keywords:

chronic kidney disease glomerulonephritis kidney transplantation viral infection

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Last Updated: Jun 30, 2025

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Area of Science:

Nephrology
Transplantation Immunology
Infectious Diseases

Background:

Glomerular damage in kidney transplants impacts graft function and survival.
Primary glomerulonephritis (GN) can recur or arise de novo post-transplant.
Viral infections like HIV, HCV, HBV, SARS-CoV-2, CMV, and BK virus can affect glomeruli.

Purpose of the Study:

To review the impact of glomerulonephritis and viral infections on kidney transplant recipients.
To highlight the importance of pre-transplant risk evaluation and post-transplant monitoring.
To emphasize the role of diagnosing and managing viral infections in transplant outcomes.

Main Methods:

Literature review on post-transplant glomerulonephritis and viral infections.
Analysis of recurrence rates and risk factors for GN.
Discussion of diagnostic approaches for viral infections in transplant patients.

Main Results:

Post-transplant GN recurrence ranges from 3% to 15%, varying by GN subtype and time post-transplant.
GN recurrence often occurs 3-5 years after kidney transplantation.
Viral infections pose significant risks to kidney transplant recipients' outcomes.

Conclusions:

Understanding GN pathophysiology aids in risk assessment and monitoring.
Prompt diagnosis and management of viral infections are vital for kidney transplant recipients.
Integrated care addressing both GN and viral infections improves graft survival.