Jove
Visualize
Contact Us

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Tumor Progression02:07

Tumor Progression

7.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.1K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Tumour Recurrence, Depth Of Invasion, And Temple Location As Independent Prognostic Parameters Of Lymph Node Metastases Of Head And Neck Cutaneous Squamous Cell Carcinomas.
  1. Home
  3. Tumour Recurrence, Depth Of Invasion, And Temple Location As Independent Prognostic Parameters Of Lymph Node Metastases Of Head And Neck Cutaneous Squamous Cell Carcinomas.

Related Experiment Video

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K

Tumour Recurrence, Depth of Invasion, and Temple Location as Independent Prognostic Parameters of Lymph Node

Zuzana Horakova1, Ivo Starek1, Jana Zapletalova2

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, I. P. Pavlova 185/6, Olomouc 779 00, Czech Republic.

International Journal of Clinical Practice
|March 18, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

More Related Videos

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

9.8K
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

10.6K

Related Experiment Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.5K
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

9.8K
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

10.6K

Identifying nodal metastases in head cutaneous squamous cell carcinoma (cSCC) is crucial. Recurrence, temple location, and infiltration depth independently predict metastases, guiding treatment for high-risk patients.

Area of Science:

  • Oncology
  • Dermatology
  • Head and Neck Surgery

Background:

  • Cutaneous squamous cell carcinoma (cSCC) has a high survival rate (>90%).
  • Nodal metastases significantly reduce survival rates by over 50%.
  • Predicting nodal metastases in head cSCC is essential for risk stratification.

Purpose of the Study:

  • To identify independent risk factors for nodal metastases in head cSCC.
  • To aid in identifying high-risk patients requiring closer follow-up and tailored treatment.
  • To evaluate the necessity of elective lymph node treatment.

Main Methods:

  • Retrospective analysis of 118 head cSCC patients (2008-2020).
  • Inclusion of tumor recurrence, location, infiltration depth, size, and T stage as risk parameters.
  • Statistical analysis to determine independent predictors of nodal metastases.

    • Main Results:

    • Tumor recurrence, temple location, and infiltration depth were independent predictors of nodal metastases.
    • These factors increased metastasis probability by 8.0, 8.1, and 4.3 times, respectively.
    • Tumor size and T stage were significant factors in univariate analysis.

    Conclusions:

    • Confirmed several independent risk factors for head cSCC nodal metastases.
    • Findings assist in identifying patients needing intensified treatment and surveillance.
    • Elective lymph node treatment is not recommended due to low metastasis incidence.