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Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects
Daniela Oliveira Werneck Rodrigues1,2, Roberta Wolp Diniz2, Leonardo Cunha Dentz1
1Department of Medicine, Centro Universitário Presidente Antônio Carlos, Juiz de Fora, MG, Brazil.
Journal of Blood Medicine
|March 18, 2024
Summary
Rosai-Dorfman Disease (RDD) is a rare histiocytosis. This study highlights RDD
Area of Science:
- Histiocytic Disorders
- Immunohistochemistry
- Rare Diseases
Background:
- Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis.
- Typically presents as massive, painless cervical lymphadenopathy, often self-limited.
- Extranodal involvement is common and can occur without lymphadenopathy.
Observation:
- Presents two distinct cases of RDD diagnosed via immunohistochemistry.
- Cases demonstrated varied clinical progressions, including complete remission and fatal outcomes.
- Highlights the diagnostic challenges due to RDD's diverse presentations.
Findings:
- Immunohistochemistry is crucial for diagnosing Rosai-Dorfman Disease.
- RDD exhibits a wide spectrum of clinical behavior and presentation.
- Differential diagnosis is complex, influenced by affected sites and symptoms.
Implications:
- Emphasizes the need to consider RDD in the differential diagnosis of lymphadenopathy.
- Underscores the importance of recognizing extranodal manifestations of RDD.
- Clinical vigilance is essential due to the potential for severe or fatal outcomes.
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