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Published on: April 1, 2019
Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential
Delin Wu1, Yuna Liu2, Yan Liu1
1Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, China.
Background:
This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma.
Methods:
Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in PubMed, Embase, Cochrane, Wanfang and CNKI. Eligible literatures were enrolled and their data were extracted. OR and its 95% CI were calculated for assessing the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. The included data were weighted by an inverse variance and then analyzed by a fixed or random effects model. Heterogeneity test and sensitivity analysis were performed on the enrolled reports. STATA12.1 and TSA (trial sequential analysis) were utilized for analyses.
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