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Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential
Delin Wu1, Yuna Liu2, Yan Liu1
1Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Department of Respiratory, Beijing, China.
Journal of Medical Biochemistry
|March 18, 2024
Summary
This study investigated the link between the LTC4S -444 A>C gene variant and asthma risk. The findings suggest this polymorphism may influence an individual's susceptibility to developing asthma.
Area of Science:
- Genetics
- Respiratory Medicine
- Epidemiology
Background:
- Asthma is a common respiratory condition with complex genetic and environmental influences.
- The leukotriene C4 synthase (LTC4S) gene plays a role in inflammatory pathways relevant to asthma.
- The -444 A>C polymorphism in the LTC4S gene is a candidate marker for asthma susceptibility.
Purpose of the Study:
- To systematically evaluate the association between the LTC4S -444 A>C polymorphism and asthma susceptibility.
- To synthesize evidence from published literature to determine the overall correlation.
Main Methods:
- A comprehensive literature search was conducted in major databases (PubMed, Embase, Cochrane, Wanfang, CNKI) up to June 1, 2019.
- Eligible studies reporting the LTC4S -444 A>C polymorphism and asthma were included.
- Meta-analysis using fixed or random effects models, with heterogeneity and sensitivity analyses, was performed using STATA12.1 and TSA.
Main Results:
- Data from eligible studies were extracted and analyzed to calculate the odds ratio (OR) and 95% confidence interval (CI).
- The meta-analysis aimed to provide a pooled estimate of the association between the LTC4S -444 A>C polymorphism and asthma risk.
- Statistical methods were employed to assess the reliability and consistency of the findings across studies.
Conclusions:
- The study aimed to clarify the role of the LTC4S -444 A>C polymorphism in asthma pathogenesis.
- Further research may be warranted to confirm the findings and explore underlying mechanisms.
- Understanding genetic predispositions like the LTC4S polymorphism can contribute to personalized asthma management strategies.
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