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Programmed Death-1 Inhibitor Immunotherapy-Induced Symptomatic Toxic Thyroid Nodule
Owen Cole1, Prahasith Kamani1, Vikash Kumar1
1Internal Medicine, The Brooklyn Hospital Center, Brooklyn, USA.
Cureus
|March 18, 2024
Summary
Programmed death-ligand 1 (PD-L1) inhibitors can cause thyroid issues. This case report details a patient developing a toxic thyroid nodule during PD-L1 inhibitor treatment, suggesting a link needing further research.
Area of Science:
- Oncology
- Immunology
- Endocrinology
Background:
- Immune checkpoint inhibitors, particularly PD-L1 inhibitors, are vital cancer therapies.
- Thyroid dysfunction is a known side effect of these treatments, commonly hypothyroidism.
- Hyperthyroidism is a less frequent but documented adverse effect.
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