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Serum elastase 1 in chronic pancreatic disease
Klinische Wochenschrift
|July 1, 1985
Summary
Serum elastase 1 and immunoreactive trypsin have limited diagnostic value for chronic pancreatic diseases. Increased levels of both enzymes often occur together, but low trypsin with normal elastase may indicate severe exocrine insufficiency.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Gastroenterology
Background:
- Chronic pancreatitis and pancreatic cancer pose significant diagnostic challenges.
- Accurate diagnosis is crucial for effective patient management and treatment.
- Biomarkers like elastase 1 and trypsin are explored for their diagnostic utility.
Purpose of the Study:
- To evaluate and compare the diagnostic usefulness of serum elastase 1 and immunoreactive trypsin.
- To assess the correlation between these two enzyme levels in pancreatic diseases.
- To identify specific patterns indicative of chronic pancreatitis and exocrine insufficiency.
Main Methods:
- Radioimmunoassay (RIA) technique used to measure serum elastase 1 and immunoreactive trypsin.
- Analysis conducted on sera from control subjects, pancreatic cancer patients, chronic pancreatitis patients, and those with extra-pancreatic diseases.
Main Results:
- Elevated elastase 1 levels were observed in 60.9% of pancreatic cancer and 61.1% of chronic pancreatitis patients.
- Low enzyme values were rare in patients with pancreatic disease.
- A strong correlation was noted between elastase 1 and trypsin levels in pancreatic cancer and chronic pancreatitis patients.
Conclusions:
- Serum elastase 1 and immunoreactive trypsin show limited diagnostic value for chronic pancreatic disease.
- Elevated levels of both enzymes typically appear concurrently.
- Low immunoreactive trypsin with normal elastase 1 may suggest severe exocrine insufficiency in chronic pancreatitis.