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A novel therapy for intractable chronic cough
Matthew Bricknell1, Chris Zi-Fan Zhao1, Natasha Smallwood2,3
1Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria Australia.
Respirology Case Reports
|March 18, 2024
Summary
Humidified high flow therapy (HHFT) significantly improved intractable chronic cough in two patients with interstitial lung disease. This therapy enhanced sleep and quality of life, suggesting a potential role for home-based treatment.
Area of Science:
- Pulmonology
- Respiratory Medicine
Background:
- Intractable chronic cough significantly impacts patients' quality of life.
- Interstitial lung disease (ILD) often presents with persistent cough.
- Current treatments for chronic cough in ILD can be limited.
Observation:
- Two female patients with ILD (Sjogren's disease with ILD, and idiopathic pulmonary fibrosis) experienced severe chronic cough.
- Both patients utilized the Fisher and Paykel myAIRVO™ system for humidified high flow therapy (HHFT).
Findings:
- Continuous HHFT led to substantial reductions in cough severity, as measured by the visual analogue scale.
- Patients reported improved sleep quality and increased social engagement.
- Potential mechanisms include reduced airway dryness, anti-inflammatory effects, and airway splinting.
Implications:
- HHFT shows promise as an effective treatment for intractable chronic cough in ILD patients.
- The findings support further investigation into domiciliary (home-based) HHFT for managing chronic respiratory conditions.
- Improved cough control can lead to significant enhancements in health-related quality of life.
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