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  1. Home
  3. Associations Of Systemic Inflammation And Senescent Cell Biomarkers With Clinical Outcomes In Older Adults With Schizophrenia.
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  3. Associations Of Systemic Inflammation And Senescent Cell Biomarkers With Clinical Outcomes In Older Adults With Schizophrenia.

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Associations of Systemic Inflammation and Senescent Cell Biomarkers with Clinical Outcomes in Older Adults with

M K Kirsten Chui1,2, Kevin Schneider1, Katherine Miclau3

  • 1Buck Institute for Research on Aging, Novato CA, USA.

Medrxiv : the Preprint Server for Health Sciences
|March 18, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Specific inflammatory cytokines, not senescence markers, are linked to worse outcomes in older adults with schizophrenia. This finding may guide future treatments for schizophrenia patients, improving their long-term physical and cognitive health.

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Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Schizophrenia is associated with accelerated aging and increased systemic inflammation, contributing to higher morbidity and mortality.
  • Understanding the interplay between inflammation, aging, and clinical outcomes in schizophrenia is crucial for developing effective interventions.
  • Older adults with schizophrenia face significant challenges in cognitive function, physical health, and mobility.

Approach:

  • This pilot study examined 24 older adults (≥55 years) with schizophrenia.
  • Assessed clinical outcomes including symptoms (Positive and Negative Syndrome Scale), neurocognition, mobility, and general health.
  • Measured serum cytokine levels to derive senescence-associated secretory phenotype (SASP) scores and correlated these with clinical measures.

Key Points:

  • Elevated levels of specific cytokines (eotaxin, IL-1α, IL-1β, IFNα) correlated with more severe negative and depressive symptoms in schizophrenia.
  • Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) were associated with poorer general physical health.
  • Eotaxin showed negative associations with mobility and global cognitive function.

Conclusions:

  • Specific inflammatory cytokines, rather than composite SASP scores, are significantly associated with clinical outcomes in older adults with schizophrenia.
  • These findings highlight the role of distinct inflammatory pathways in the pathophysiology of schizophrenia-related aging.
  • Further research into targeted anti-inflammatory therapies could improve long-term health and function in this population.