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Updated: Jun 30, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

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Published on: June 28, 2019

Coronary Microvascular Function Following Severe Preeclampsia.

Michael C Honigberg^1,2, Katherine E Economy³, Maria A Pabón⁴

¹Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Medrxiv : the Preprint Server for Health Sciences

|March 18, 2024

Summary

This summary is machine-generated.

Severe preeclampsia is linked to reduced coronary microvascular function in the early postpartum period. This suggests preeclampsia may increase long-term cardiovascular disease risk through microvascular dysfunction.

Keywords:

cardiac positron emission tomography coronary microvascular function preeclampsia pregnancy women’s health

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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Published on: January 26, 2024

Area of Science:

Cardiovascular Research
Obstetrics
Translational Medicine

Background:

Preeclampsia, a pregnancy-specific hypertensive disorder, involves angiogenic protein imbalance.
Microvascular dysfunction is implicated in preeclampsia-associated cardiovascular risk.

Approach:

Cardiac positron emission tomography (PET) assessed myocardial flow reserve (MFR), myocardial blood flow (MBF), and coronary vascular resistance (CVR) in women postpartum and controls.
Soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) levels were measured.

Key Points:

Women with severe preeclampsia showed reduced MFR, lower stress MBF, and higher stress CVR compared to non-postpartum controls.
Normotensive pregnancy outcomes were intermediate.
MFR improved with time postpartum; sFlt-1/PlGF ratio correlated with MBF.

Conclusions:

Reduced coronary microvascular function is observed early postpartum following severe preeclampsia.
Preeclampsia-related systemic microvascular dysfunction may involve the coronary microcirculation.
Further research is needed to develop interventions mitigating cardiovascular disease risk.