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A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies
José Alejandro Bohórquez1,2,3, Sitaramaraju Adduri1,2, Danish Ansari1,2,3
1Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Biorxiv : the Preprint Server for Biology
|March 18, 2024
Summary
Researchers developed a humanized mouse model to study tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection. This model mimics human immune responses and disease progression, offering a valuable tool for HIV-TB research.
Area of Science:
- Immunology
- Infectious Diseases
- Animal Models
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), and human immunodeficiency virus (HIV) are significant global health threats.
- HIV-Mtb co-infection severely impacts hosts, increasing active TB risk by 15-21 times.
- A suitable animal model is crucial for understanding HIV-Mtb co-infection's complex immune dynamics.
Conclusions:
- Humanized NSG-SGM3 mice effectively model HIV and Mtb co-infection at pathological, immunological, and metabolic levels.
- This model provides a reliable small animal system for advancing basic and translational research in HIV-Mtb co-infection.
- The model's ability to recapitulate human responses makes it a promising tool for therapeutic development.
