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Related Experiment Video

Updated: May 2, 2026

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

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Published on: August 18, 2018

Bacteria Invade the Brain Following Sterile Intracortical Microelectrode Implantation.

Jeffrey Capadona¹, George Hoeferlin¹, Sarah Grabinski¹

¹Case Western Reserve University.

Research Square

|March 18, 2024

Summary

Microelectrode implantation damages the blood-brain barrier (BBB), allowing gut bacteria into the brain. This impacts brain-machine interface performance and neuroinflammation, highlighting a new mechanism affecting brain health.

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Published on: June 8, 2022

Area of Science:

Neuroscience
Biomedical Engineering
Microbiome Research

Background:

Brain-machine interface (BMI) performance is limited by neuroinflammation, often caused by blood-brain barrier (BBB) damage from intracortical microelectrodes.
Gut bacteria may enter the brain, potentially exacerbating BBB disruption and influencing brain health.

Conclusions:

Intracortical microelectrode implantation can lead to bacterial invasion of the brain, impacting the microbiome-gut-brain axis.
This bacterial infiltration contributes to neuroinflammation and affects chronic BMI performance.
The findings suggest a novel mechanism influencing brain health and device longevity after implantation.