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Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
Published on: September 30, 2014
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Persistent Interruption in Parvalbumin Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms
Carol M Upchurch1, Christopher J Knowlton1, Simon Chamberland2
1Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112.
Biorxiv : the Preprint Server for Biology
|March 18, 2024
Summary
Persistent interruption of firing in hippocampal PV-INs, driven by Kv1 currents, enables robust working memory. This mechanism, crucial for disinhibition, supports persistent activity in principal cells.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Cellular Electrophysiology
Background:
- Persistent activity in principal cells is theorized to maintain memory traces during working memory.
- Previous work demonstrated persistent interruption of firing in fast-spiking parvalbumin-expressing interneurons (PV-INs).
- This interruption may facilitate persistent activity in principal cells via disinhibition lasting hundreds of milliseconds.
Conclusions:
- Persistent interruption of firing is a broadly applicable mechanism for PV-INs across brain regions.
- The Kv1 current provides a robust biophysical substrate for this persistent firing interruption in hippocampal CA1 PV-INs.
- Robustness to noise is conferred by the presence of a slow variable, like Kv1 inactivation.
