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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
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Developmental trajectory of cortical somatostatin interneuron function
Alex Wang1, Katie A Ferguson1, Jyoti Gupta1
1Department of Neuroscience, Kavli Institute for Neuroscience, Wu Tsai Institute, Yale University School of Medicine, New Haven, CT 06510 USA.
Biorxiv : the Preprint Server for Biology
|March 18, 2024
Summary
Early in development, somatostatin-expressing interneurons (SST-INs) in the visual cortex gain feature selectivity. Their inhibitory impact on pyramidal neurons (PNs) strengthens, establishing a crucial circuit normalization mechanism.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- GABAergic inhibition is vital for neocortical circuit development, yet the roles of specific inhibitory interneuron subtypes are not fully understood.
- Somatostatin-expressing interneurons (SST-INs) target dendrites of pyramidal neurons (PNs) in mature cortex, influencing synaptic integration and plasticity.
Conclusions:
- A developmental window exists for the emergence of inhibitory circuit mechanisms for normalization.
- Early visual cortex development involves the maturation of SST-INs and their integration into local circuits.
- This study clarifies the developmental trajectory of SST-INs and their contribution to cortical circuit function.
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