Correlation Between miR-497-5p Expression With Clinicopathological Characteristics and Prognosis in Patients With Breast Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Low expression of miR-497-5p in breast cancer tissues is linked to poorer prognosis and increased mortality risk. This microRNA serves as an independent predictor of death in breast cancer patients.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Breast cancer (BC) is a heterogeneous disease with diverse biological and histological features.
- MicroRNAs (miRNAs) play critical roles in cancer development and progression, influencing patient prognosis.
- Understanding specific miRNA roles, like miR-497-5p, is crucial for improving breast cancer management.
Purpose Of The Study
- To investigate the association between miR-497-5p expression and clinicopathological characteristics in breast cancer patients.
- To evaluate the prognostic value of miR-497-5p in predicting overall survival in breast cancer.
- To determine if miR-497-5p functions as an independent risk factor for mortality in breast cancer.
Main Methods
- Quantitative analysis of miR-497-5p expression in 140 breast cancer tissues and adjacent normal tissues using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
- Correlation analysis between miR-497-5p expression levels and clinicopathological features (age, tumor size, grade, stage, lymph node metastasis).
- Survival analysis and multivariate Cox regression modeling to assess the impact of miR-497-5p on patient prognosis and its role as an independent risk factor for death.
Main Results
- miR-497-5p was significantly downregulated in breast cancer tissues compared to normal adjacent tissues.
- Lower miR-497-5p expression correlated with larger tumor size, advanced clinical stage, and lymph node metastasis.
- Patients with low miR-497-5p expression exhibited significantly decreased overall survival.
Conclusions
- Downregulation of miR-497-5p in breast cancer tissues is associated with adverse clinicopathological features.
- Low miR-497-5p expression is a significant predictor of poor prognosis and reduced survival in breast cancer patients.
- miR-497-5p represents an independent risk factor for mortality in breast cancer, highlighting its potential as a therapeutic target or biomarker.
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