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Association Between Aortic Wall Parameters on Multidetector Computed Tomography and Ruptured Plaques By
Masatsugu Miyagawa1, Keisuke Kojima1, Kurara Takahashi1
1Division of Cardiology, Department of Medicine Nihon University School of Medicine Tokyo Japan.
Journal of the American Heart Association
|March 18, 2024
Summary
Nonobstructive general angioscopy (NOGA) detects aortic plaque ruptures (PRs) associated with increased aortic wall thickness and area on CT scans. These findings highlight CT
Area of Science:
- Cardiovascular Imaging
- Vascular Biology
- Medical Diagnostics
Background:
- Nonobstructive general angioscopy (NOGA) identifies vulnerable plaques in the aortic lumen, potential risk factors for cardiovascular events like embolism.
- The correlation between computed tomography (CT) findings and NOGA-detected vulnerable plaques remains unclear.
Purpose of the Study:
- To investigate the association between CT-measured aortic parameters and NOGA-identified aortic plaque ruptures (PRs).
- To determine if CT can detect early signs of plaque vulnerability identified by NOGA.
Main Methods:
- 101 patients underwent NOGA and contrast-enhanced CT.
- Aortic wall thickness, aortic wall area (AWA), and AWA in the vascular area were measured on CT scans.
- Association between CT measurements and NOGA-derived PRs was assessed.
Main Results:
- NOGA detected aortic PRs in 22.1% of evaluated vertebral levels.
- PRs were significantly associated with greater aortic wall thickness, AWA, and AWA in the vascular area on CT (P<0.001).
- PR frequency increased with aortic wall thickness; some PRs were visible on CT in near-normal intima.
Conclusions:
- NOGA-derived PRs strongly correlate with increased aortic wall thickness, AWA, and AWA in the vascular area on CT.
- NOGA can detect PRs in the intima that may appear nearly normal on CT scans.
- CT measurements may aid in identifying aortic vulnerable plaques.
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