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Updated: Jun 30, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave-Assisted One-Pot Telescoped Synthesis of 2-Amino-1,3-thiazoles, Selenazoles, Imidazo[1,2-a]pyridines, and
Pablo Macías-Benítez1, Alfonso Sierra-Padilla1, Francisco M Guerra1
1Departamento de Química Orgánica e Instituto de Biomoléculas, Facultad de Ciencias, Universidad de Cádiz, Polígono Río San Pedro s/n., 11510 Puerto Real, Cádiz, Spain.
Abstract:
Primary and secondary alcohols have been converted into 2-amino-1,3-thiazoles under microwave irradiation, employing trichloroisocyanuric acid (TCCA) as a dual oxidant and chlorine source, TEMPO as a co-oxidant, and thiourea. Secondary alcohols underwent a single-stage, one-pot conversion process, while primary alcohols required a two-stage, one-pot procedure. Both transformations were completed within minutes (25-45 min). The versatility of this protocol extends to the synthesis of other heterocycles, including 1,3-selenazoles, 2-aminoimidazoles, imidazo[1,2-a]pyridines, quinoxalines, and hydrazino thiazoles by replacing thiourea with the appropriate surrogates.
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