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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

A Poly Aptamer Encoded DNA Nanocatcher Informs Efficient Virus Trapping.

Yunhua Guo¹, Wenzhe Song¹, Yuhang Dong¹

¹State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.

|March 18, 2024

Summary

This summary is machine-generated.

Scientists developed a DNA nanocatcher platform using aptamers to trap and inhibit viruses, including SARS-CoV-2 variants. This broad-spectrum antiviral approach prevents infection by capturing entire virus particles effectively.

Keywords:

Aptamer Biomaterials DNA nanotechnology Nanomedicine Virus neutralization

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Area of Science:

Biotechnology and Nanomedicine
Virology and Infectious Diseases

Background:

Existing broad-spectrum antiviral platforms are insufficient to combat global public health threats.
There is a critical need for novel strategies to effectively neutralize diverse viral pathogens.

Purpose of the Study:

To develop a novel poly aptamer-encoded DNA nanocatcher platform for broad-spectrum antiviral applications.
To demonstrate the efficacy of the DNA nanocatcher in trapping and inhibiting viral infections, including SARS-CoV-2 variants.

Main Methods:

Synthesized ultralong single-stranded DNA (ssDNA) scaffolds decorated with repeated aptamers via a biocatalytic process.
Mineralized magnesium pyrophosphate onto the ssDNA to create nanocatchers with interfacial nanocaves.
Optimized nanocatcher size to prevent cellular uptake and enhance virus trapping via multisite synergistic interactions.

Main Results:

Successfully developed a DNA nanocatcher platform capable of trapping entire virus particles.
Demonstrated broad virus-trapping capability, effectively engulfing SARS-CoV-2 variants.
Showcased significant inhibition of virus infection to host cells by the DNA nanocatchers.

Conclusions:

The poly aptamer-encoded DNA nanocatcher platform offers a promising broad-spectrum antiviral strategy.
This innovative approach effectively traps viruses and inhibits infection, addressing limitations of current antiviral platforms.
The nanocatcher technology shows potential for combating emerging viral threats and enhancing global public health security.