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Systematic review of survival following liver or lung metastasectomy for metastatic anal squamous cell carcinoma

  • 0Swansea Bay University Health Board, UK.
Annals of the Royal College of Surgeons of England +

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March 18, 2024

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March 18, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Metastatic anal squamous cell carcinoma (SCC) survival outcomes after metastasectomy are limited but show potential. Further research is needed to standardize reporting and improve treatment strategies for this rare cancer.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Evidence-Based Medicine

Background

  • Metastatic anal squamous cell carcinoma (SCC) has a poor prognosis.
  • Limited evidence exists for surgical resection of metastases in anal SCC.
  • This study aimed to determine survival outcomes for patients undergoing metastasectomy for anal SCC.

Purpose Of The Study

  • To establish survival outcomes for patients with metastatic anal SCC undergoing metastasectomy.
  • To review current literature on liver and/or lung metastasectomy for anal SCC.
  • To identify gaps in reporting and areas for future research.

Main Methods

  • Systematic review of MEDLINE, Embase, Cochrane, and PubMed databases.
  • Inclusion criteria: Stage IV anal SCC patients (>18 years) undergoing metastasectomy.
  • Primary outcome: Overall survival. Secondary outcomes: Disease-free survival, morbidity, quality of life. Risk of bias assessed using ROBINS-I.

Main Results

  • 10 studies included 98 patients; heterogeneity in results reporting.
  • One-year overall survival for liver metastasectomy: 87%. Three-year: 53%. Five-year: 38%.
  • Median survival for lung metastasectomy: 24 months. Quality of life data was not reported. Significant risk of bias identified in most studies.

Conclusions

  • The evidence base for metastasectomy in metastatic anal SCC is limited.
  • Standardized outcome reporting is necessary for future treatment guidance.
  • Further research is required to inform optimal treatment strategies.

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