Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer

Area of Science:

• Immunology
• Oncology
• Biochemistry

Background:

• Interleukin 12 (IL-12) is a cytokine crucial for immune regulation and adaptive immunity.
• IL-12 comprises p35 and p40 subunits, exhibiting complex interactions within cytokine families.
• IL-12 demonstrates significant therapeutic potential across diverse tumor types.

Conclusions:

• Interleukin 12 (IL-12) is a potent immunomodulatory cytokine with significant therapeutic potential in oncology.
• IL-12 presents a promising strategy for colorectal cancer treatment, including its potential as a radiosensitizer.
• Further research into IL-12-based therapies could lead to novel treatment approaches for CRC.