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Morphological and Functional Correlations in Acute Central Serous Chorioretinopathy
Peter Kiraly1,2,3, Maja Šuštar Habjan4, Jaka Smrekar5
1Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.
Documenta Ophthalmologica. Advances in Ophthalmology
|March 18, 2024
Summary
Subretinal fluid and retinal thickness in acute central serous chorioretinopathy (CSC) correlate with visual function deficits. Retinal sensitivity measured by microperimetry is a better indicator than visual acuity for research in CSC.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Acute central serous chorioretinopathy (CSC) is a condition affecting the retina.
- Understanding the relationship between structural changes and visual function is crucial for managing CSC.
Purpose of the Study:
- To evaluate the correlations between morphological and functional parameters in patients with acute CSC.
- To identify key indicators of visual function impairment in acute CSC.
Main Methods:
- A prospective study included 50 patients with acute CSC.
- Assessments comprised optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG).
- Correlation analysis was performed between OCT-derived morphological parameters (subretinal fluid height [SRF], central retinal thickness [CRT], macular volume [MV]) and functional parameters.
Main Results:
- Subretinal fluid (SRF) demonstrated the strongest correlations with functional parameters.
- Average retinal sensitivity (MP-A) showed the most robust negative correlation with morphological parameters.
- Weak correlations were found between BCVA and morphological parameters, while contrast sensitivity and mfERG showed weak to moderate correlations.
Conclusions:
- Subretinal fluid (SRF) and central retinal thickness (CRT) are representative morphological proxies for visual function deficits in acute CSC.
- Retinal sensitivity measured by microperimetry (MP) may be superior to best-corrected visual acuity (BCVA) in clinical research and in-depth visual function evaluations for CSC.
