Advances in Fluorescent Nanosensors for Detection of Vitamin B₁₂

Vitamin B₁₂ plays a significant role in maintaining human health. Deficiency or excess intake of vitamin B₁₂ may cause some diseases. Therefore, it is significant to fabricate sensors for sensitive assay of vitamin B₁₂. In the past few years, a variety of nanomaterials have been developed for the fluorescence detection of vitamin B₁₂ in tablets, injection, human serum and food. In the review, the assay mechanisms of fluorescent nanomaterials for sensing vitamin B₁₂ were first briefly discussed. And the progress of various nanomaterials for fluorescence detection of vitamin B₁₂ were systematically summarized. Furthermore, the sensing performance of fluorescent nanosensors was compared with fluorescent probes. Lastly, the challenges and perspectives about the topic were presented.