The inflammation score predicts the prognosis of gastric cancer patients undergoing Da Vinci robot surgery

Xihao Chen ^1,2, Yichao Zhang ¹, Zhiyu Liu ^1,2

⁰Xijing Hospital, Fourth Military Medical University, Department of Gastrointestinal Surgery, Xi'an, 710032, China.

Journal of Robotic Surgery +

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March 18, 2024

View abstract on PubMed

Summary

The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of survival in gastric cancer patients after Da Vinci robotic surgery. This simple blood marker, along with a developed nomogram, offers accurate prognosis for these patients.

Area Of Science

Oncology
Surgical Oncology
Immunology

Background

The neutrophil-to-lymphocyte ratio (NLR) is a recognized survival predictor in various cancers.
Limited research exists on NLR's predictive value in gastric cancer patients undergoing robotic surgery.
This study addresses the prognostic significance of NLR in this specific patient cohort.

Purpose Of The Study

To investigate the predictive value of NLR in gastric cancer patients after Da Vinci robotic-assisted surgery.
To compare NLR's prognostic ability against other inflammation and tumor biomarkers.
To develop a predictive model for overall survival.

Main Methods

Retrospective analysis of 128 gastric cancer patients treated with Da Vinci robotic surgery.
Evaluation of NLR, PLR, LMR, SII, PNI, CA125, CA19-9, CA72-4, CEA, and AFP.
Utilized ROC curves, AUC, Kaplan-Meier curves, and multifactorial Cox analysis for prognostic assessment.
Constructed a nomogram based on significant predictive factors.

Main Results

NLR, LMR, CEA, AFP, primary tumor location, tumor size, and TNM stage were significant predictors of overall survival (OS).
Multivariate Cox analysis identified NLR, LMR, and AFP as independent hematological predictors.
A nomogram based on NLR demonstrated excellent predictive performance at 1, 3, and 5 years (AUCs ranging from 0.773 to 0.781).

Conclusions

Neutrophil-to-lymphocyte ratio (NLR) is a simple yet potent marker for predicting survival outcomes in gastric cancer patients post-Da Vinci robotic surgery.
The NLR-based nomogram provides a visual and accurate tool for prognosis prediction.
NLR holds considerable predictive significance in this surgical context.

Keywords:

Da Vinci robot surgery Gastric cancer Neutrophil-to-lymphocyte ratio Nomogram Prognosis Survival