JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Prognostic value of tumor deposits and positive lymph node ratio in stage III colorectal cancer: a retrospective cohort study

  • 0Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University.
International Journal of Surgery (london, England) +

|

March 18, 2024

|

March 18, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Tumor deposits (TD) and lymph node ratio (LNR) are independent predictors of colorectal cancer (CRC) survival. Combining TD and LNR improves risk stratification for stage III CRC patients, identifying those with the worst prognosis.

Area Of Science

  • Oncology
  • Gastroenterology
  • Cancer Research

Background

  • Tumor deposits (TD) are currently used for N staging only in node-negative colorectal cancer (CRC) patients.
  • The prognostic value of TD combined with lymph node ratio (LNR) in stage III CRC remains unclear.

Purpose Of The Study

  • To evaluate the prognostic value of tumor deposits (TD) and lymph node ratio (LNR) in stage III colorectal cancer (CRC).
  • To assess the combined prognostic impact of TD and LNR on cancer-specific survival (CSS) and overall survival (OS).

Main Methods

  • Analysis of 31,139 stage III CRC patients from SEER database (training) and Chinese hospitals (validation).
  • Kaplan-Meier method and Cox regression models were used to assess associations of TD and LNR with CSS and OS.

Main Results

  • Both TD-positive status and high LNR (≥0.4) were significantly associated with worse CSS in both training and validation sets.
  • Patients with TD-positive and high LNR had a substantially increased risk of CRC-specific death (HR 4.09-4.60).
  • The combination of TD and LNR demonstrated the highest predictive value for CSS and showed good discriminative ability in a nomogram.

Conclusions

  • Tumor deposits (TD) and lymph node ratio (LNR) are independent prognostic predictors in stage III colorectal cancer.
  • The combination of TD and LNR can effectively identify high-risk patients for colorectal cancer-specific death.