Related Experiment Video

Updated: Jun 30, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

10.7K

NLRP3 inflammasome in sepsis: don't overlook the small steps-they can make a big difference!

Felicie Belicard1,2, Karin Tarte1,2, Jean-Marc Tadié1,2,3

  • 1Department of Infectious Diseases and Intensive Care Unit, CHU Rennes, 35000 Rennes, France.

Journal of Leukocyte Biology
|March 18, 2024
PubMed

Insights

Persistent NLRP3 activation in sepsis drives myeloid-derived suppressor cell expansion and elevates Interleukin-10 (IL-10) levels. This highlights a key pathway in sepsis-induced immune dysregulation.

Area of Science:

  • Immunology
  • Molecular Biology
  • Critical Care Medicine

Background:

  • Sepsis involves complex immune dysregulation.
  • NLRP3 inflammasome activation is implicated in inflammatory diseases.
  • Myeloid-derived suppressor cells (MDSCs) play a role in immune suppression.
Keywords:
NLRP3 inflammasomeimmunosuppressionsepsis

More Related Videos

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

20.9K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.1K

Related Concept Videos

Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K