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Vaccination of Adults With Cancer: ASCO Guideline
Mini Kamboj1, Kari Bohlke2, Deana M Baptiste3
1Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY.
Summary
Vaccinating adults with cancer is crucial for limiting infection severity and preventing illness. Optimizing vaccination status, including timely administration and revaccination, is a key component of cancer care.
Area of Science:
- Oncology
- Infectious Diseases
- Vaccinology
Background:
- Adults with solid tumors or hematologic malignancies are at increased risk of infectious complications.
- Existing guidelines for cancer patient vaccination require updates based on recent evidence.
Purpose of the Study:
- To provide evidence-based recommendations for the vaccination of adults with cancer.
- To guide healthcare providers in optimizing vaccination status for cancer patients and their contacts.
Main Methods:
- Systematic literature review of systematic reviews, RCTs, and nonrandomized studies from 2013 to 2023.
- Inclusion of studies on vaccine efficacy and safety in cancer patients and household contacts.
- Convening of an Expert Panel by ASCO to review evidence and formulate recommendations.
Main Results:
- 102 publications were included: 24 systematic reviews, 14 RCTs, and 64 nonrandomized studies.
- The majority of evidence focused on the efficacy and safety of COVID-19 vaccines in this population.
- Evidence also addressed other relevant vaccines for immunocompromised individuals.
Conclusions:
- Optimizing vaccination status is a critical aspect of cancer care, aiming to reduce infection severity and prevent disease.
- Recommendations include documenting vaccination status, timely vaccine administration, and appropriate revaccination post-transplant or therapy.
- Collaboration among healthcare providers and vaccination of household contacts are essential for comprehensive protection.
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