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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

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Related Experiment Video

Updated: Jun 29, 2026

Isolation of Primary Rat Hepatocytes with Multiparameter Perfusion Control
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Technical considerations for isolated limb perfusion: A consensus paper.

Andrew J Hayes1, David J Coker2, Lukas Been3

  • 1Department of Academic Surgery, Royal Marsden Hospital, London, UK; Institute of Cancer Research, London, UK.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|March 18, 2024
PubMed
Summary
This summary is machine-generated.

Isolated limb perfusion (ILP) expert guidelines were developed using a Delphi process to standardize high-dose chemotherapy delivery for extremity cancers. These consensus recommendations cover all procedural aspects, ensuring safe and effective treatment.

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Area of Science:

  • Surgical Oncology
  • Medical Oncology
  • Clinical Practice Guidelines

Background:

  • Isolated limb perfusion (ILP) is a specialized procedure for advanced extremity cancers, delivering high-dose chemotherapy.
  • The technique, though established, is used in few centers, necessitating standardized practices.
  • Combining chemotherapy with TNFα requires careful monitoring to prevent systemic toxicity.

Purpose of the Study:

  • To establish unified technical consensus guidelines for Isolated Limb Perfusion (ILP).
  • To streamline ILP practice and guide centers new to the technique.
  • To ensure consistent and safe administration of ILP for extremity malignancies.

Main Methods:

  • A modified Delphi process involving face-to-face, online, and hybrid meetings.
  • Iterative refinement and recirculation of a consensus document over two years (Oct 2021 - Oct 2023).
  • Achieving greater than 90% consensus on all recommendations.

Main Results:

  • A consensus document with 23 topics achieved >90% agreement.
  • 83% of recommendations reached 100% consensus among working group members.
  • Recommendations encompass pre-operative assessment, drug administration, perfusion, monitoring, logistics, and post-operative care.

Conclusions:

  • The first expert-based consensus statement on technical aspects of ILP.
  • Provides a reference for existing and new centers performing ILP.
  • Aims to standardize and improve the safety and efficacy of ILP procedures.