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Updated: Jun 30, 2025

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Early childhood neurodevelopmental milestones in children with allergic diseases: the Japan Environment and

Abir Nagata1,2, Kazunari Onishi3, Toshio Masumoto4

  • 1Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita-shi, Osaka, 565-0871, Japan. abir.med@osaka-u.ac.jp.

Scientific Reports
|March 19, 2024
PubMed

Insights

Early childhood allergies like atopic dermatitis and asthma did not impact neurodevelopment. However, food allergy (FA) showed a slight association with gross motor skill delays in young children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Developmental Pediatrics
  • Epidemiology

Background:

  • Early childhood allergic diseases are common.
  • Neurodevelopmental milestones are crucial for early childhood assessment.
  • The relationship between allergies and neurodevelopment requires further investigation.

Purpose of the Study:

  • To investigate the association between early childhood allergic diseases and neurodevelopmental milestone attainment.
  • To examine specific allergic conditions: atopic dermatitis (AD), asthma, and food allergy (FA).
  • To assess neurodevelopment across multiple domains in the first three years of life.

Main Methods:

  • Prospective birth cohort study in Japan (n=87,986).
  • Assessed physician-diagnosed/caregiver-reported allergies and neurodevelopment using Ages and Stages Questionnaires (ASQ).
  • Used stabilized inverse probability-weighted GEE models to estimate odds ratios (ORs).

Main Results:

  • No significant association found between atopic dermatitis (AD) or asthma and delays in communication, gross motor, fine motor, problem-solving, or personal-social skills.
  • Children with food allergy (FA) had a higher likelihood of gross motor delay (weighted adjusted OR: 1.14).
  • No significant association between FA and other developmental domains was observed.

Conclusions:

  • Early childhood allergic diseases generally do not appear to influence neurodevelopmental delays.
  • A potential association exists between food allergy (FA) and gross motor skill delays.
  • Routine developmental monitoring and further research are recommended for children with FA.

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