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Updated: Jun 30, 2025
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
MR-guided percutaneous microwave coagulation of small breast tumors
Ying Ji1, Yaoyao Zhuo2, Ting Li3
1Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China.
Background:
To evaluate the technical success and patient safety of magnetic resonance-guided percutaneous microwave coagulation (MR-guided PMC) for breast malignancies.
Methods:
From May 2018 to December 2019, 26 patients with breast tumors measuring 2 cm or less were recruited to participate in a prospective, single-institution clinical study. The primary endpoint of this study was the evaluation of treatment efficacy for each patient. Histochemical staining with α-nicotinamide adenine dinucleotide and reduced (NADH)-diaphorase was used to determine cell viability following and efficacy of PMC. The complications and self-reported sensations from all patients during and after ablation were also assessed. The technical success of the PMC procedure was defined when the area of the NADH-diaphorase negative region fully covered the hematoxylin-eosin (H&E) staining region in the tumor.
Results:
All patients had a complete response to ablation with no residual carcinoma on histopathological specimen. The mean energy, ablation duration, and procedure duration per tumor were 36.0 ± 4.2 kJ, 252.9 ± 30.9 S, and 104.2 ± 13.5 min, respectively. During the ablation, 14 patients underwent prolonged ablation time, and 1 patient required adjusting of the antenna position. Eleven patients had feelings of subtle heat or swelling, and 3 patients experienced slight pain. After ablation, one patient took two painkillers because of moderate pain, and no patients had postoperative oozing or other complications after PMC. Induration around the ablation area appeared in 16 patients.
Conclusion:
MR-guided PMC of small breast tumors is feasible and could be applied in clinical practice in the future.
Critical Relevance Statement:
MR-guided PMC of small breast tumors is feasible and could be applied in clinical practice in the future.
Key Points:
• MR-guided PMC of small breast tumors is feasible. • PMC was successfully performed for all patients. • All patients were satisfied with the final cosmetic result.
Insights
Magnetic resonance-guided percutaneous microwave coagulation (MR-guided PMC) is a safe and effective treatment for small breast tumors. This minimally invasive procedure demonstrated high technical success rates and patient satisfaction with excellent cosmetic outcomes.
Area of Science:
- Oncology
- Medical Imaging
- Minimally Invasive Procedures
Background:
- Breast malignancies pose a significant health concern, necessitating advanced treatment options.
- Minimally invasive techniques are increasingly preferred for breast cancer treatment.
- Magnetic resonance-guided percutaneous microwave coagulation (MR-guided PMC) offers a novel approach for localized tumor ablation.
Purpose of the Study:
- To assess the technical success and patient safety of MR-guided PMC for small breast tumors (≤2 cm).
- To evaluate the efficacy of MR-guided PMC in achieving complete tumor ablation.
- To document patient-reported outcomes, including complications and satisfaction.
Main Methods:
- A prospective, single-institution study included 26 patients with small breast tumors.
- MR-guided PMC was performed, with technical success defined by complete tumor coverage in ablation zones.
- Histochemical staining (NADH-diaphorase, H&E) assessed cell viability and treatment efficacy.
Main Results:
- All 26 patients achieved complete tumor ablation with no residual carcinoma post-procedure.
- The mean ablation energy was 36.0 ± 4.2 kJ, with a mean ablation duration of 252.9 ± 30.9 seconds.
- Minor complications included transient heat/swelling (11 patients), slight pain (3 patients), and moderate pain requiring analgesia (1 patient); 16 patients experienced post-procedure induration.
Conclusions:
- MR-guided PMC is a feasible and safe treatment modality for small breast tumors.
- The procedure demonstrated high technical success and efficacy in achieving complete tumor destruction.
- Patients reported satisfaction with the cosmetic results, suggesting potential for future clinical application.
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