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The Application of Nanotechnological Therapeutic Platforms against Gynecological Cancers
Vahideh Keyvani1,2,3, Samaneh Mollazadeh4, Espanta Riahi5,6
1Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:
Gynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved bioavailability of various cargos. This review summarizes the application of different nanoplatforms, such as lipid-based, metal- based, and polymeric nanoparticles, to improve the chemo/radio treatments of GC. In the following work, the use of nanoformulated agents to fight GCs has been mentioned in various clinical trials. Although nanosystems have their own challenges, the knowledge highlighted in this article could provide deep insight into translations of NPs approaches to overcome GCs.
Insights
Nanoparticle delivery systems offer improved cancer treatment by enhancing drug efficacy and reducing side effects for gynecological cancers (GCs). This review explores various nanoplatforms for better chemo/radiotherapy against ovarian, cervical, and uterine cancers.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Gynecological cancers (GCs) like ovarian, cervical, and endometrial cancers have poor prognoses.
- Current treatments face limitations including side effects, low efficacy, and therapeutic resistance.
Purpose of the Study:
- To review the application of nanoplatforms for improving gynecological cancer treatment.
- To explore how nanotechnology can overcome limitations in current chemo/radiotherapy.
Main Methods:
- Review of literature on nanoplatforms (lipid-based, metal-based, polymeric nanoparticles) for gynecological cancer therapy.
- Analysis of clinical trial data on nanoformulated agents against GCs.
Main Results:
- Nanoparticle delivery systems show potential for targeted delivery, reduced toxicity, controlled release, and improved bioavailability.
- Various nanoplatforms are being investigated to enhance chemo/radiotherapy for GCs.
Conclusions:
- Nanosystems offer a promising approach to overcome the limitations of conventional gynecological cancer treatments.
- Further research and clinical translation of nanoparticle-based therapies are crucial for improving patient outcomes in GCs.
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