Analyses of hypoxia-related risk factors and clinical relevance in breast cancer
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies key hypoxia-related genes and prognostic factors in breast cancer subtypes. A novel risk model may improve individual treatment strategies for breast cancer patients.
Area Of Science
- Oncology
- Genomics
- Bioinformatics
Background
- Hypoxia significantly influences breast cancer progression, including heterogeneity, metastasis, relapse, and drug resistance.
- Understanding hypoxia-related biological signatures is crucial for developing effective breast cancer treatments.
Purpose Of The Study
- To explore hypoxia-related biological signatures across different breast cancer subtypes.
- To identify key prognostic factors for breast cancer patients using bioinformatics methods.
- To construct a hypoxia-related risk model for breast cancer.
Main Methods
- Utilized The Cancer Genome Atlas (TCGA) Breast Cancer datasets.
- Employed single-sample gene set enrichment analysis (ssGSEA) to classify samples into immune-activated/suppressed groups.
- Applied hierarchical clustering to distinguish hypoxic and non-hypoxic populations within immune-suppressed samples to build a risk model.
Main Results
- Identified Nuclear factor interleukin-3 regulated (NFIL3), serpin family E member 1 (SERPINE1), FOS, biglycan (BGN), epidermal growth factor receptor (EGFR), and sushi-repeat-containing protein, X-linked (SRPX) as key hypoxia-related genes.
- Established margin status, AJCC stage, hypoxia status, ER/PR status, NFIL3, SERPINE1, EGFR, and risk score as independent prognostic indicators.
- Validated the model's statistical significance and feasibility through survival curves and immunohistochemical staining.
- Observed higher hypoxia-related risk scores in ER/PR+ and HER2+ breast cancer subtypes, while ER/PR-negative samples showed more activated immune pathways and better drug response.
Conclusions
- Developed a novel risk model and identified potential prognostic factors for breast cancer.
- The findings offer new perspectives for personalized breast cancer treatment strategies.
- The study highlights the importance of hypoxia in breast cancer and its potential as a therapeutic target.
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