Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bactericidal activity of cefazedone.

E Dingeldein

    Arzneimittel-Forschung
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Cefazedone (Refosporen) exhibits distinct bactericidal activity against Staphylococcus aureus and Escherichia coli. Its effectiveness is enhanced when combined with gentamicin, proving bactericidal even at low concentrations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Elution kinetics and antimicrobial effects of gentamicin- and clindamycin-loaded bone cements in vitro].

    Zeitschrift fur Orthopadie und Unfallchirurgie·2008
    Same author

    Plasma transglutaminase factor XIII induces microvessel ingrowth into biodegradable hydroxyapatite implants in rats.

    Biomaterials·2004
    Same author

    Influence of sterilization upon a range of properties of experimental bone cements.

    Journal of materials science. Materials in medicine·2004
    Same author

    [Nanoparticulate silver. A new antimicrobial substance for bone cement].

    Der Orthopade·2004
    Same author

    [Vacuum mixing systems for bone cement completion - comparison of different systems].

    Zeitschrift fur Orthopadie und ihre Grenzgebiete·2002
    Same author

    Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.

    The Journal of antimicrobial chemotherapy·2001
    Same journal

    Wirksamkeit und Verträglichkeit eines pflanzlichen Arzneimittels mit Kapuzinerkressenkraut und Meerrettich bei akuter Sinusitis, akuter Bronchitis und akuter Blasenentzündung im Vergleich zu anderen Therapien unter den Bedingungen der täglichen Praxis.

    Arzneimittel-Forschung·2013
    Same journal

    Abstracts of the Paul-Martini-Stiftung Symposium 2012 in combination with the National Academy of Leopoldina. November 16-17, 2012. Berlin, Germany.

    Arzneimittel-Forschung·2013
    Same journal

    Leave-one-out procedure in the validation of elimination rate constant analysis.

    Arzneimittel-Forschung·2012
    Same journal

    Pharmacokinetic and myocardial enzyme profiles of two administration routes of epirubicin in breast cancer patients.

    Arzneimittel-Forschung·2012
    Same journal

    Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.

    Arzneimittel-Forschung·2012
    Same journal

    Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.

    Arzneimittel-Forschung·2012
    See all related articles

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Cefazedone (Refosporen) is an antibiotic with a defined chemical structure: (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylic acid.
    • Understanding the in vitro activity of antibiotics is crucial for guiding clinical treatment decisions.

    Purpose of the Study:

    • To evaluate the distinct bactericidal activity of cefazedone against common bacterial pathogens.
    • To assess the influence of physiological fluids (serum, bile, urine) on cefazedone's activity.
    • To investigate the synergistic bactericidal effect of combining cefazedone with gentamicin.

    Main Methods:

    • In vitro susceptibility testing of cefazedone against strains of Staphylococcus aureus, Escherichia coli, and Proteus mirabilis.

    Related Experiment Videos

  • Comparative analysis of cefazedone's bactericidal activity in nutrient broth, serum, bile, and urine.
  • Evaluation of the combined bactericidal effect of cefazedone and gentamicin.

    • Main Results:

    • Cefazedone demonstrated distinct bactericidal activity against Staphylococcus aureus and Escherichia coli strains.
    • Activity was less pronounced against Proteus mirabilis.
    • Cefazedone exhibited enhanced activity in serum and bile compared to nutrient broth, but reduced activity in urine.
    • The combination of cefazedone and gentamicin showed significant bactericidal effects at low concentrations.

    Conclusions:

    • Cefazedone possesses notable in vitro bactericidal properties against key Gram-positive and Gram-negative bacteria.
    • Physiological conditions, such as the presence of urine, can modulate cefazedone's efficacy.
    • The combination therapy of cefazedone and gentamicin offers a potent bactericidal strategy.