Dosimetric impact of voxel resolutions of computational human phantoms for external photon exposure

Several research teams have developed computational phantoms in polygonal-mesh (PM) and/or Non-Uniform Rational B-Spline format, but it has not been systematically evaluated if the existing voxel phantoms are still dosimetrically valid. We created three voxel phantoms with the resolutions of 1,000, 125, and 1 mm³ and simulated the irradiation in antero-posterior geometry with photons of 0.1, 1, and 10 MeV using voxel Monte Carlo codes, and compared the energy deposition to their organs/tissues with the values from the original PM phantom using mesh Monte Carlo codes. The coefficient of variation in energy deposition overall showed about five-fold decrease as the voxel resolution increased but differences were mostly less than 5% for any voxel resolution. We conclude that PM phantoms and mesh Monte Carlo techniques may not be necessary for external photon exposure (0.1 - 10 MeV) and the existing voxel phantoms can provide enough dosimetric accuracy in those exposure conditions.