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Updated: Jun 30, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.2K

Role of circular RNAs in lung cancer

Maksat Babayev1, Patricia Silveyra1

  • 1Department of Environmental and Occupational Health, Indiana University School of Public Health Bloomington, Bloomington, IN, United States.

Frontiers in Genetics
|March 19, 2024
PubMed

Insights

Circular RNAs (circRNAs) are key in lung cancer. This review explores their role in diagnosis, mechanisms, and future research for lung adenocarcinoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Lung cancer is a major global health issue.
  • Circular RNAs (circRNAs) are increasingly recognized for their roles in various diseases.
  • circRNAs show potential as oncogenes or tumor suppressors in cancer development.

Purpose of the Study:

  • To review current research on circRNAs in lung cancer.
  • To highlight the diagnostic and mechanistic roles of circRNAs.
  • To identify knowledge gaps and future research directions.

Main Methods:

  • Literature review of recent studies on circRNAs and lung cancer.
  • Analysis of circRNA involvement in lung adenocarcinoma progression.
  • Synthesis of findings regarding circRNA biomarkers and therapeutic targets.

Main Results:

  • circRNAs play significant roles in lung cancer, especially lung adenocarcinoma.
  • circRNAs are implicated in both oncogenic and tumor-suppressive functions.
  • Emerging evidence supports circRNAs as potential biomarkers for lung cancer diagnosis and prognosis.

Conclusions:

  • circRNAs are promising targets for lung cancer diagnosis and therapy.
  • Further research is needed to fully elucidate circRNA functions and clinical applications.
  • Understanding circRNAs can lead to improved lung cancer management strategies.
Keywords:
CircRNAsNSCLCbiomarkerscircular RNAlung adenocarcinomalung cancer

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