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State-of-the-art in transposable element modulation affected by drugs in malignant prostatic cancer cells

Anna Terrazzan1,2, Riccardo Vanini1, Pietro Ancona1

  • 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Journal of Cellular Biochemistry
|March 19, 2024
PubMed

Insights

Transposable elements (TEs) are implicated in prostate cancer progression. Research suggests certain antiviral drugs and chemotherapy may reduce TEs, offering new therapeutic avenues.

Area of Science:

  • Genomics
  • Cancer Biology
  • Pharmacology

Background:

  • Transposable elements (TEs) are increasingly recognized for their role in cancer development.
  • Their specific functions and interactions with genes in prostate cancer remain an active area of research.

Purpose of the Study:

  • To review the association between transposable elements (TEs) and genes in prostate cancer.
  • To examine the impact of various drug treatments on TE activity and expression in prostate cancer.
  • To explore the potential of targeting TEs in prostate cancer therapy.

Main Methods:

  • Literature review of articles from the PubMed database.
  • Construction of gene-TE and drug-TE interaction networks.
  • Analysis of TE expression patterns in response to different chemical drugs.

Main Results:

  • Specific TE types were linked to the expression of transcripts involved in carcinogenesis.
  • Different drug treatments exhibited unique patterns of TE reactivation.
  • Evidence suggests a correlation between antiviral drugs, chemotherapy, and reduced TE expression in prostate cancer patients.

Conclusions:

  • Transposable elements play a significant role in prostate cancer progression and gene expression.
  • Drug treatments can modulate TE activity, with potential implications for cancer therapy.
  • Antiviral drugs and chemotherapy may represent a strategy to reduce TEs in prostate cancer.
Keywords:
antiviralsepigeneticsprostate carcinomarepetitive elementstransposons

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