Related Experiment Video
Updated: Jun 30, 2025
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
Development and applications of peri-implantitis mouse models.
Jianwei Zhang1, Zian Tong1, Long Chen1
1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Mouse models are increasingly used to study peri-implantitis, a common implant complication. This review summarizes methods for inducing peri-implantitis in mice and their applications in understanding disease pathogenesis and developing treatments.
Area of Science:
- Dental Implantology
- Oral Microbiology
- Animal Models in Research
Background:
- Peri-implantitis is a frequent complication following dental implant placement.
- The precise pathogenesis of peri-implantitis remains incompletely understood.
- Mouse models are emerging as valuable tools for peri-implantitis research.
Purpose of the Study:
- To review and synthesize methods for inducing peri-implantitis in mouse models.
- To outline the current applications of these mouse models in peri-implantitis research.
Main Methods:
- Systematic review of literature on peri-implantitis mouse models.
- Analysis of various induction methods, including silk ligatures, Porphyromonas gingivalis (Pg) gavage, and lipopolysaccharide (LPS) injection.
- Evaluation of model applications in pathogenesis, treatment exploration, and disease interaction studies.
Main Results:
- Silk ligature, Pg gavage, and LPS injection successfully induced peri-implantitis in mice.
- Induction periods ranged from 2-4 weeks for ligatures and 6 weeks for gavage/injection.
- Mouse models offer advantages like mature gene editing, low cost, and rapid induction.
Conclusions:
- Mouse models effectively replicate peri-implantitis and are applicable for studying pathogenesis, non-surgical treatments, and disease interactions.
- Despite advantages, limitations exist compared to large animal models.
- Further research utilizing mouse models can advance understanding and treatment of peri-implantitis.
