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Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for

Renshuai Zhang1, Songbo Xie1, Jie Ran1

  • 1Shandong Provincial Key Laboratory of Animal Resistance Biology, Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China.

Journal of Cellular Physiology
|March 19, 2024
PubMed

Insights

Proteolysis Targeting Chimeras (PROTACs) offer a novel therapeutic approach for targeted protein degradation, particularly in oncology. Further research is needed to expand their application across diverse diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Proteolysis Targeting Chimeras (PROTACs) utilize the ubiquitin-proteasome system for targeted protein degradation.
  • This technology holds significant promise for therapeutic drug development, especially in oncology.

Purpose of the Study:

  • To review various types of PROTACs, including peptide-based, nucleic acid-based, and small molecule PROTACs.
  • To discuss innovative PROTAC strategies for targeting previously undruggable proteins.
  • To explore the broader therapeutic potential of PROTACs beyond oncology.

Main Methods:

  • Literature review of existing PROTAC technologies and strategies.
  • Analysis of different PROTAC modalities and their applications.
  • Discussion of emerging trends and future directions in PROTAC development.

Main Results:

  • PROTACs offer diverse approaches to targeted protein degradation.
  • Innovative strategies like bridged and conditional PROTACs enhance targeting precision.
  • The potential of PROTACs extends to various diseases beyond cancer.

Conclusions:

  • PROTACs represent a significant advancement in targeted protein degradation therapies.
  • Continued research and interdisciplinary collaboration are crucial for maximizing PROTACs' therapeutic potential.
  • Integration of computational tools will drive new treatment avenues for various diseases.
Keywords:
PROTACsdegradationdiseaseubiquitination

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