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Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.

Sai S Patkar^1,2, Bin Wang¹, Ana Maria Mosquera¹

¹Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|March 19, 2024

Summary

This summary is machine-generated.

Intrinsically disordered protein polymers (IDPPs) enable the creation of advanced, stimuli-responsive biomaterials. By combining disordered and ordered protein segments, researchers are designing novel materials with enhanced structural diversity and nanoscale organization.

Keywords:

disordered proteins peptides phase transitions self-assembly supramolecular assembly

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Area of Science:

Biomaterials Science
Protein Engineering
Supramolecular Chemistry

Background:

Intrinsically disordered proteins (IDPs) possess unique properties suitable for advanced material development.
Their recombinant derivatives, intrinsically disordered protein polymers (IDPPs), offer tunable characteristics for multistimuli-responsive materials.
Sequence-encoded disorder and phase separation in IDPs/IDPPs facilitate the creation of multifunctional materials.

Purpose of the Study:

To review strategies for enhancing the structural diversity of elastin-like polypeptides (ELPs) and resilin-like polypeptides (RLPs).
To explore the self-assembly of these polypeptides through genetic fusion with ordered motifs.
To highlight the design of hybrid biomaterials leveraging order-promoting and thermoresponsive building blocks.

Main Methods:

Genetic fusion of intrinsically disordered protein polymers (IDPPs) with ordered domains (e.g., helical, beta sheet).
Engineering of elastin-like polypeptides (ELPs) and resilin-like polypeptides (RLPs) for enhanced structural diversity.
Harnessing synergistic interactions between order-promoting and thermoresponsive elements.

Main Results:

Achieved enhanced structural diversity in ELPs and RLPs through genetic engineering.
Demonstrated self-assembly into well-structured supramolecular materials ordered on the nanoscale.
Successfully designed hybrid biomaterials exhibiting stimuli-responsive behavior.

Conclusions:

Intrinsically disordered protein polymers (IDPPs) are versatile platforms for creating sophisticated biomaterials.
The strategic combination of disordered and ordered protein segments leads to advanced stimuli-responsive and self-assembled materials.
These hybrid biomaterials hold promise for applications requiring nanoscale organization and tunable responses.