Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Middle Meningeal Artery Embolization With n-Butyl Cyanoacrylate in Patients With Chronic Subdural Hematoma: A Randomized Clinical Trial.

JAMA neurology·2026

Same author

Diagnostic cerebral angiography: A report of the SNIS Standards and Guidelines Committee, endorsed by ANZSNR and ESMINT.

Journal of neurointerventional surgery·2026

Same author

Comparison of two novel options for resuspension of inverted U-shaped nasopharyngeal flap following endonasal access to cranio-vertebral junction: Pilot cadaveric analysis and illustrative case report.

Neurosurgical review·2026

Same author

Venous Drainage Patterns of the Cavernous Sinus: A Retrospective Angiographic Analysis.

AJNR. American journal of neuroradiology·2025

Same author

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage.

Annals of clinical and translational neurology·2025

Same author

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case-Control Study.

Annals of clinical and translational neurology·2025

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

Genetics of ischemic stroke functional outcome.

Troy P Carnwath¹, Stacie L Demel², Charles J Prestigiacomo³

¹University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. carnwatp@mail.uc.edu.

Journal of Neurology

|March 19, 2024

Summary

Genetic variations significantly impact long-term disability after ischemic stroke. Identifying these genetic polymorphisms can personalize patient care and improve recovery outcomes.

Keywords:

Genetics Genomics Ischemic stroke Molecular pathophysiology Precision medicine Stroke outcome

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Jul 12, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

Area of Science:

Neurology
Genetics
Personalized Medicine

Background:

Ischemic stroke is a leading cause of long-term disability and global health burden.
Genetic factors play a crucial role in post-stroke recovery and functional outcomes.
Current understanding of genetic influences on stroke recovery requires comprehensive cataloging.

Purpose of the Study:

To compile and describe genetic polymorphisms associated with post-stroke functional outcomes.
To identify specific genetic variants linked to disability metrics like the modified Rankin Scale and Barthel Index.
To provide a foundation for personalized medicine approaches in stroke recovery.

Main Methods:

Systematic review of genetic polymorphisms related to stroke outcome scores.
Analysis of identified variants across diverse biological systems.
Correlation of genetic variants with established post-stroke disability metrics.

Main Results:

Identified 74 known genetic polymorphisms associated with post-stroke disability.
These variants are linked to 48 distinct features influencing recovery.
Affected biological systems include inflammation, vascular homeostasis, metabolism, and the p53 pathway.

Conclusions:

Genetic polymorphisms significantly influence functional outcomes after ischemic stroke.
Understanding these variants is key to developing personalized treatment strategies.
This catalog provides a basis for leveraging genetic information to maximize stroke survivor recovery.